UFR de Physique

Propositions de stages en laboratoire -- M2

Les offres sont actualisées en mai. Par exemple, les offres de stages pour l'année universitaire 2015-2016 seront mises en place en mai 2015, les offres de stages pour l'année universitaire 2016-2017 seront mises en place pour en mai 2016, etc.

Transdermal skin patch: a new approach for photothermal-triggered permeation of drugs through the skin

  • Option Finalisée « Physicien des hopitaux » du parcours Physique Biologique et Médicale
  • Laboratoire: Autre (Autre)
  • Responsable du stage: Sabine Szunerits (, )
  • Co-responsable(s): Pier Luca Palla (IEMN) (pier-luca.palla@univ-lille1.fr)
  • Mots clés: Computer modeling; thermal properties; thermal diffusion

The development of a skin-mounted patch capable of controlled transcutaneous delivery of therapeutics through thermal activation provides a unique solution for the controlled release of active principles over long-term periods. In a previous project, we developed a flexible transdermal patch for photothermal triggered release of ondansetron (ODS), a commonly used drug for the treatment of chemotherapy-induced nausea and vomiting and used as model compound here. To achieve this, a dispersion of ODS-loaded reduced graphene oxide (rGO-ODS) nanosheets were deposited onto Kapton, to produce a flexible polyimide-based patch. It was demonstrated that ODS loaded Kapton/rGO patches have a high drug delivery performance upon irradiation with a continuous laser beam at 980 nm for 10 min due to an induced photothermal heating effect. The stage of 5 months consists in developing a numerical model of the heat transfer between the ODS-Kapton patch and the skin layers, by means of classical thermal theory. The objective is to characterize the temperature field distribution and the thermal gradients, which allow ODS molecules to diffuse from the patch to the skin of the patient. The typical model to build would be centered around a simplified, finite-difference code (likely in 2D) to solve the heat transport equations in the heterogeneous structure of the patch skin multilayer. The set-up of the structure and experimental data will be discussed with the IRI (now IEMN) chemistry group, and the mathematical model will be mainly developed at the IEMN laboratory. No prerequisites are needed; however a basic knowledge of computer modeling, programming, Unix/Linux based OS system, will be a useful starting point for the candidate.